| Solution Information | help | |
| Enzyme: | Signal transducer and activator of transcription 3 [702-738,740-752] | |
| inhibitor: | BDBM43697 | |
| substrate: | n/a | |
| Solution Type: | Aqueous | |
| pH at Preparation: | n/a | |
| Temp. Prep.: | n/a | |
| Comments: | Assay Overview: The purpose of this assay is to determine whether a subset of compounds identified as active in a previous set of experiments entitled, "Primary cell-based high throughput screening assay to measure STAT1 activation" (PubChem AID 932), and that confirmed activity in a set of experiments entitled, "Confirmation cell-based high throughput screening assay to measure STAT1 activation" (AID 1262), were nonselective activators due to activation of STAT3. The compounds selected for testing in this AID met the following criteria: 1) they were declared active in AID 932 and AID 1262; 2) they were declared inactive in a set of experiments entitled, "Primary cell-based high throughput screening assay to measure STAT3 activation" (AID 871); 3) they were inactive in a set of experiments entitled, "Counterscreen assay for STAT1 activators: cell-based high throughput assay to measure NF-kappaB activation" (AID 1306); and 4) they were inactive in a set of experiments entitled, "Count | |
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